Abstract: Parkinson’ s Disease ( PD) is a neurodegenerative disease, mainly manifested by motor symptoms such as resting tremor, muscle rigidity, bradykinesia and postural instability, accompanied by mental and cognitive disorders and autonomic dysfunction and other non-motor symptoms. The degeneration and death of dopamine (DA) neurons in the substantia nigra is the main feature of PD , and its pathological sign is the formation of Lewy bodies. People have established a variety of animal models to study different aspects of PD. Disease models can be used base on neurotoxin or gene method in non-human primates ( NHP ) , rodents, zebrafish, C. elegans, drosophila and other animals, the models prepared are to simulate the pathological changes of PD, and have their own advantages and limitations. At present, the PD model induced by 1-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine (MPTP) is more and more widely used in medical research.

Key words: Parkinson’ s disease, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) , animal models

摘要： 帕金森病 ( PD) 是一种神经退行性疾病,主要表现为静止性震颤、肌强直、运动徐缓及姿势不稳等运动症状, 同时伴有精神和认知障碍、自主神经功能障碍等非运动症状。 PD 的主要特征是黑质多巴胺 ( DA) 能神经元变性 和死亡,其病理性标志是路易小体 ( LB) 形成。 人们建立了多种动物模型来研究 PD 的不同方面,疾病模型可以通 过基于神经毒素或基因的方法在非人类灵长类 (NHP) 、啮齿动物、斑马鱼、秀丽隐杆线虫和果蝇等动物中产生,制 备的模型都是 模 拟 PD 部 分 病 理 改 变, 有 其 各 自 的 优 势 和 局 限 性。 目 前, 1-甲 基-4-苯 基-1, 2, 3, 6-四 氢 吡 啶 (MPTP) 诱导的 PD 模型在医学领域的研究中应用越来越广泛。

关键词: 帕金森病, 1-甲基-4-苯基-1,2,3,6-四氢吡啶 (MPTP) , 动物模型